This study investigated the importance of Supplier Segmentation to the manufacturing sector of Ghana; using selected manufacturing companies the in Eastern and Volta regions of Ghana as case study. Managing relationships between a supplier and buyer can be a complex one. Each party seeks to maximize its time, resources, and cash investment; these may be competing priorities that can strain the relationship. While certain companies adopt a more collaborative approach in dealing with suppliers, others too adopt a take it or leave it approach. In the midst of this controversy, it became necessary to conduct a research to assess the importance of supplier segmentation which has been hailed as a key component of Supplier Relationship Management. The case studies for this study were the management of Volta Star Company Ltd, Akosombo Textiles and the Intravenous infusions Limited. Based on the simple random, purposive, and quota sampling techniques 60 managers from these companies were sampled. The study revealed that Supplier Segmentation is highly important to the Ghanaian manufacturing sector.